Inhibiting Hsp90 chaperone roles using 17AAG induces cytostasis or apoptosis in tumor cells through destabilization of several mutated cancer promoting proteins.Although mitochondria are central in deciding the fate of cells, 17AAG induced effects on tumor cell mitochondria were largely unknown.Here, we show that Hsp90 inhibition with 17AAG first a
Abstract Multiple myeloma (MM) is an incurable blood cancer that primarily affects older adults.Several frailty tools have been developed to address the heterogeneity of aging in this population.Uptake of these measures has been variable, leading to a gap in knowledge regarding the proportion of enrolled trial participants considered frail and unce
Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII).EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and therefore, EnhII/Cp is essential for the Institutionnel - Triathlon Sherbrooke - Enfant regulation of HBV
The paper is a critical review of two recently published monographs on the subject of the Tablet Organiser everyday and banal forms of nationalism in the post-socialist countries of Europe and Asia.The authors of the monographs, drawing on the theories of national identity and nationhood by Benedict Anderson, Ernest Gellner, Eric Hobsbawm, Michael
Abstract Background Imbalances of gut microbiota composition are linked to a range of metabolic perturbations.In the present study, we examined the gut microbiota of women with gestational Institutionnel - Triathlon Sherbrooke - Enfant diabetes mellitus (GDM) and normoglycaemic pregnant women in late pregnancy and about 8 months postpartum.Methods